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Review Article | OPEN ACCESS

Exosomes: Salivary Biomarkers?

Zeeshan Qamar1,2 , Fayez Hussain Niazi3, Syed Bilal Tanveer4, Tayyaba Zeeshan5

1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Riyadh Em University, Riyadh, Saudi Arabia; 2Department of Oral Biology, Faculty of Dentistry, Liaquat College of Medicine and Dentistry, Karachi, Pakistan; 3Department of Restorative and Prosthetic Dentistry, Dar Al Uloom University; 4Department of Preventive Dental Sciences, College of Dentistry, Dar al uloom University, Riyadh, Saudi Arabia; 5Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University Malaya, Kuala Lumpur, Malaysi.

For correspondence:-  Zeeshan Qamar   Email: zeeshan.qamar@riyadh.edu.sa   Tel:+966538672265

Accepted: 26 February 2020        Published: 31 March 2020

Citation: Qamar Z, Niazi FH, Tanveer SB, Zeeshan T. Exosomes: Salivary Biomarkers?. Trop J Pharm Res 2020; 19(3):667-672 doi: 10.4314/tjpr.v19i3.30

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Saliva is a bio-fluid considered similar to blood in that it contains various DNAs, RNAs and proteins. Therefore, it is a fluid with diagnostic potential. In recent time, exosomes are emerging as nano-vesicles which enhance intra-cellular communication. Exosomal content, which is dependent on the cell of origin, reflects physiological status of cells. Exosomes have potentials for use as biomarkers for variant diseases, based on their stability and availability in various body fluids. Current studies have proposed the role of exosomes as immuno-modulators in the etiology of auto-immune diseases and cancers. The present study focused on the role of exosomes as biomarkers and their therapeutic potentials in particular diseases related to the oral cavity

Keywords: Exosomes, Auto-immune, Biomarkers, Saliva, Diagnosis

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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